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KMID : 0377619870520010035
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Korean Jungang Medical Journal
1987 Volume.52 No. 1 p.35 ~ p.41
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Studies on Changes in Heart Rate and Blood Pressure Induced by Intraventricular Ketamine in Rabbits
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Abstract
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In this study, an attempt was made to determine heart rates and blood pressures in the whole rabbits in order to investigate the effects of ketamine, which is known as an anesthetic drug, on the sympathetic nervous system (pressor action) and the cardiovascular dynamics (positive chronotropic action).
Ketamine, when administered intraventricularly, produced the prolonged hypertensive responses and an increased heart rates in the whole rabbits. The pressor responses and positive chronotropic effects induced by ketamine were not affected by phentolamine-treatment. Ketamine-evoked hypertensive responses and the positive chronotropic effects were inhibited by clonidine-treatment. Yohimbine-treatment, while reducing positive chro-notropic action evoked by ketamine, did not attenuate ketamine-induced pressor action. From the above results, it is thought that intraventricular ketamine produces the marked pressor response and the positive chronotropic effects via adrenergic presynaptic receptor located in brain.
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